Mission Bio

Mission Bio is a life science company specializing in targeted single-cell DNA sequencing and multiomics. Its technology helps researchers move beyond the averaged results of bulk sequencing to understand the genetic and phenotypic differences between individual cells.

The company’s core product, the Tapestri® Platform, enables researchers to analyze thousands of individual cells and determine which mutations occur together within the same cellular populations. Depending on the selected workflow, Tapestri can combine targeted genomic analysis with surface-protein measurements or targeted gene-expression data, connecting genotype with phenotype in the same cell.

Tapestri can be used to investigate:

• Clonal architecture and evolution
• Rare cellular populations
• Mutation co-occurrence and zygosity
• SNVs, indels and copy-number alterations
• Treatment response, resistance and relapse
• Genome-editing outcomes
• Genomic and phenotypic heterogeneity

The platform is particularly suited to research in hematological malignancies, solid tumors, precision medicine, pharmaceutical development, and cell and gene therapy. Predesigned and customizable targeted panels allow researchers to focus sequencing resources on biologically relevant genes and genomic regions.

Mission Bio provides an integrated workflow covering cell encapsulation, molecular barcoding, targeted amplification, sequencing-library preparation and bioinformatic analysis. The result is a detailed view of how individual clones differ, evolve and respond—information that can remain hidden in conventional bulk measurements.